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Dietary and endogenous enzymatic and nonenzymatic antioxidants counteract the damaging effects of free radicals by various mechanisms, such as electron donation, catalytic removal, or binding radicals and/or gene expression regulation

Significance Usually, glutathione is an antioxidant that occurs in every cell of the body while glutamine is an amino acid, a building block of a protein

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However, Mito-TEMPO treatment significantly decreased this apoptotic index which can be inferred as protective effect of Mito-TEMPO against 5-FU-induced injury