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Subsequently, it was shown that IMC-A12 could decrease tumour growth in a transgenic mouse model of pancreatic neuroendocrine carcinogenesis when the IR level was decreased, demonstrating that the effect on tumour growth depends on the IR and IGF1R composition 25

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[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Bates, D., Mchler, M., Zurich, E., Bolker, B

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