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Historical DSIP Pain Research The evidence consists largely of animal studies and very small uncontrolled human observations

For Asian men, the recommended age for initiation of surveillance is 40 years

This means that while the association is clear and the mechanisms are well-hypothesized, definitive answers about causation, dose-response relationships, and optimal prevention remain areas of active investigation

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The primary outcome measurements of the study included change in body weight from baseline to week 26