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The mobile phases were MS solvent A (5% ACN, 0.1% FA) and B (90% ACN, 0.1% FA) at a flow rate of 0.2 ml/min with the gradient (the proportion of MS solvent B is given in%) represented in the Supplementary Table 2

The activity of NRF2 is highly dependent on several signaling pathways, including protein kinase RNAlike endoplasmic reticulum kinase (PERK) pathway and mitogenactivated protein kinase (MAPK) pathway, making it a complex and contextdependent transcription factor [79, 80]

Although CD44 is not involved in paracetamol pharmacokinetics, it is implicated in the inflammatory response to liver injury [43]

Dynamic expression of candidalysin facilitates oral colonization of Candida albicans in mice

Cells were washed and incubated with Cy-3 or Cy-5 conjugated secondary antibodies (Jackson ImmunoResearch Laboratories, West Grove, PA and Thermofisher)