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Insufficient human clinical data Most research on AOD-9604 has been conducted in animals or short-term human trials, making it difficult to determine its full long-term effects

10.1300/J092v11n01_02 20 CashA.KaufmanD

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That said, "no serious toxicity in animal models" is not the same as "proven safe in humans long-term," and anyone with a personal or family history of cancer should treat the angiogenic mechanism above as a genuine reason to talk to a qualified clinician before starting