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Upon Akt activation, Foxo proteins are phosphorylated and sequestered in the cytoplasm, preventing them from functioning as transcription factors

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Fattal-Valevski A., Azouri-Fattal I., Greenstein Y.J., Guindy M., Blau A., Zelnik N

doi: 10.1016/j.jconrel.2011.02.022

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One of the most common signs is the development of dark spots and hyperpigmentation, particularly in areas most exposed to environmental pollutants