Biomaterials used for bone tissue engineering generally include biodegradable polymers, bioceramics, bioactive glasses, and composite materials that integrate both components.Polymers such as poly (lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL) offer controllable degradability, flexibility, and ease of processing, making them ideal for drug encapsulation and sustained release.Bioceramics, including hydroxyapatite (HA) and -tricalcium phosphate (-TCP), exhibit excellent osteoconductivity and chemical similarity to natural bone minerals, facilitating cell adhesion and bone integration
5.5 Exosomes Exosomes are small vesicles secreted by cells that carry a variety of nucleic acids and proteins
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Whereas autophagy can degrade large macromolecular complexes and even entire organelles, the UPS is characterized by exquisite substrate specificity, targeting only ubiquitinated proteins while preserving intact cellular structures
Aging Cell
Pharmacology 61(3):154166 Townsend DM, Tew KD, Tapiero H (2003) The importance of glutathione in human disease
