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Vitamin B-12 is a water-soluble B complex vitamin found naturally in a variety of foods, including meat, fish and dairy products and is also added to some foods

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Pre-publication history The pre-publication history for this paper can be accessed here: Additional information Competing interests The authors declare that they have no competing interests

From a health economics perspective, lifelong B12 supplementation should involve cost-effective delivery routes and tailored dosages to optimise clinical outcomes while minimising excess

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