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Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats

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8 weeks: ~3 vials (~2.24 mg) 12 weeks: ~4 vials (~3.64 mg) 16 weeks: ~6 vials (~5.04 mg) Insulin Syringes (U-100, 0.5 mL or 1 mL) Per injection: 1 syringe 8 weeks (once daily): ~56 syringes 16 weeks (once daily): ~112 syringes Bacteriostatic Water (10 mL bottles) Use 3.0 mL per 1 mg vial for reconstitution

Together, these studies argue that FSP1 can represent (1) a context-dependent essentiality (for example, metastatic niches) and/or (2) a stand-alone oxidative defense node that becomes rate limiting for tumor survival under physiological stressors encountered in vivo