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Studies on GSTO1-1 also suggested a protective effect of this enzyme on PD, exerted through the inhibition of the active form of interleukin-1 (IL-1 ) which is a critical factor in inflammatory response 47,58

10,11,81,82 Specifically, TLR-2, TLR-4, and the myeloid differentiation primary response protein 88 (MyD88) are crucial to the inflammatory reaction of macrophages to uric acid crystals

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Animal models for human polycystic ovary syndrome (PCOS) focused on the use of indirect hormonal perturbations: A review of the literature