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In a study investigating the mechanism of this effect, researchers used pancreatic tissue fragments from normal and diabetic rats

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An association of the IL1RN *2 allele with increased serum ceruloplasmin levels was also reported (this observation applies only to patients without the p.H1069Q mutation in one or both ATP7B alleles)

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Ca 2+ also activates the cysteine protease calpain-1, which degrades cytoskeletal proteins such as the ankyrin-R complex, promoting membrane blebbing and increasing cellular adhesiveness (Restivo et al., 2021)