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With the development of IR, an unfavorable, reverse flux of FFAs toward non-adipose tissues, such as the liver, occurs

GHK-Cu initiates gene expression changes (upregulation of collagen I, decorin, superoxide dismutase, and downregulation of MMP-1) that persist for 4872 hours after the peptide itself has been metabolized and excreted

The documented research protocol is once-daily dosing in the activation phase (roughly weeks 1-4), then the same per-dose amount at a reduced 3-5x/week frequency in maintenance

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