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Although palmitoylation was not assessed here, PA-driven changes in protein palmitoylation may represent an additional mechanism contributing to ENS dysfunction in high-fat states and will require dedicated investigation

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Informed consent was obtained from all participants (no compensation involved)

To systematically elucidate these heterogeneous factors, the following sections will explore four interconnected pathogenic axes that illustrate how ferroptosis cooperatively disrupts the structural integrity and homeostatic function of periodontal tissues

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