CXXC5 is overexpressed in bald scalps and plays a direct role in suppressing hair growth through Wnt pathway inhibition
Overall, the evidence base is promising, the safety profile is encouraging, and clinical outcomes especially under properly designed protocols can be significant
However, if serum cobalamin concentration is within the normal range, treatment should be continued at least monthly and the owner should be forewarned that clinical signs may recur sometime in the future
Gentle Swirling: Hold the vial and swirl it in a slow, circular motion
The skin of the individual is damaged by the sun
Given that EtOH-induced mitochondrial dysfunction and ER stress are intimately involved in the pathogenesis of ALD, future studies to examine these pathways under the current experimental setting will provide important mechanistic information underlying the protection seen in GCLM KO mice