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Despite HRT improves postmenopausal complications, the prolonged use of HRT was not recommended now due to its influence on the development of certain types of cancers

Bibcode:2002FEBSL.511..145R

The appearance of drusen, typically following the formation of BLamD, further disrupts RPE organization, placing both mechanical and physiological stress on the surrounding RPE cells, which results in cell death [29]

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