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Why nature chose phosphate to modify proteins

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This fatty shell is made of the same material as your own cell membranes

The demonstrated importance of protecting the terminals to pharmacokinetic characteristics suggests numerous additional synthetic approaches that may be applicable including the insertion of non-peptide linkages (see Sardinia et al., 1994) between the first and second amino acids, the replacement of the N-terminal amino acid with a non- amino acid, and N-terminal acylation

Pandian, N

Tannic acid-modified silver nanoparticles for enhancing anti-biofilm activities and modulating biofilm formation