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Database (Oxford) 2021:baab012

The proteome was analyzed using label-free mass spectrometry, followed by targeted validation immunoassays of key findings

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Results of preclinical and in vitro studies have shown that activation of the IRR requires concentrations of ARA 290 greater than or equal to ~1 nmol/L (~1.3 ng/mL) (14)

Studies have found for example that simvastatin inhibits the proliferation, invasion, and migration of the ovarian cancer cell lines OVCAR3 and SKOV3, thereby possibly exhibiting anti-metastatic effects also in ovarian cancer in vivo [88, 89]

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