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The network comprised 59 pathways in total, including 21 pathways in the Most Studied Pathways, 26 in the Gene-Associated Pathways, and 24 in the Popular Pathways (Fig

doi:10.1042/BST0330811

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For example, in certain embodiments, a sustained and/or extended release formulation described herein comprises a combination of poloxamer 407 (pluronic F127) and carboxymethylcellulose (CMC) in a ratio of about 40:1, about 35:1, about 30:1, about 25:1, about 20:1, about 15:1, about 10:1, or about 5:1.4%, about 4.5%, or about 5% of the total weight of the formulation or composition