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This is the major route of elimination of HNE and other electrophiles that conjugate with GSH

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However, significant data gaps remain: No completed, peer-reviewed human safety trial for synthetic Epitalon has been published in Western scientific literature Pharmacokinetics, tissue distribution, and immunogenicity in human subjects remain uncharacterised Long-term safety data across human populations does not currently exist Interactions with other compounds have not been systematically studied Any research involving Epitalon must be conducted under appropriate institutional ethical oversight, with full compliance with relevant research governance frameworks