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Discontinuation of chronic opioid administration has been suggested to mediate a similar effect on brain norepinephrine systems as exposure to stressors (Koob et al., 2004)

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Although the short-term effect of nicotine may lead to that rush feeling, there are also negative short-term effects associated with it like: Nausea Dizziness Anxiety Insomnia Restlessness Conclusion In the obscured landscape of cigarette nicotine content, discerning the brands with the highest levels can be a challenge