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It all comes down to each peptides unique composition in their raw state

A composition of GHK-Cu peptide (copper tripeptide) for avoiding first pass metabolism comprising a topically applied composition comprising from GHK-Cu or copper tripeptide, polymer and one or more penetration enhancers

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Miethke M

Other rare side effects might include liver problems (indicated by yellowing of the skin or eyes), changes in blood cell counts, and severe skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis