Additional research is still needed to focus on these mechanisms, but the evidence currently available supports the notion that chromium has potential as an adjunct therapy in the management of PCOS ( Despite conflicting results, chromium is still discussed in relation to PCOS because a number of studies show improvements in menstrual cyclicity and insulin sensitivity, which may be advantageous for some individuals
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In accordance with this, pathway analysis of the RNA transcriptome identified oestrogen-mediated S-phase entry, p53 signalling and G1/S checkpoint regulation as canonical pathways significantly modulated in response to GSTO1 knockdown (Supplementary Fig
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