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The reaction mixture consisted of 1.53 mL phosphate buffer (0.05 M, pH 7.0), 0.1 mL of ethylene diaminetetra acetic acid (1 mM), 0.1 mL of sodium azide (1 mM), 0.1 mL of glutathione (1 mM), 0.1 mL of NADPH (0.2 mM), 0.01 mL of hydrogen peroxide (0.25 mM) and 0.02 mL of PMS in a final volume of 3 mL

Front Endocrinol (Lausanne) (2022) 13:825934

Notably, PF-05221304 combined with PF-06865571 (Diacylglycerol O-Acyltransferase 2 (DGAT2) inhibitor) has the potential to avoid some limitations of ACC inhibitor alone, including the ACC inhibitor-mediated elevation in serum TG (NCT03776175)

& De Belleroche, J

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