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Severe allergic reactions to B12 shots are uncommon but can happen

Vitamin B12 deficiency Having trouble absorbing vitamin B12 from food, lacking intrinsic factors (for example, as a result of pernicious anaemia), having gastrointestinal surgery, taking certain medications for an extended period of time (such as metformin or proton pump inhibitors), and nutritional deficiencies are all causes of vitamin B12 deficiency

In short evidence exists, but it is not revolutionary

Across all clinical trials, the side effect profile was consistently described as indistinguishable from placebo

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