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The first uptake is of glutamate and GABA into astrocytes, where a large fraction is converted to glutamine in an energy-requiring process, and the second uptake is that of glutamine into neurons

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Some studies have suggested that sUA was thought to be a preservation mechanism that evolved during human evolution due to its 90% reabsorption, implying that sUA has beneficial effects (20)

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These changed proteins assemble with chronological age resulting in apoptosis (Arlia Ciommo, 2018)