4 Research on disulfidptosis-associated CNS disease 4.1 Neurodegenerative disease 4.1.1 Alzheimers disease Alzheimers disease (AD) is a prevalent condition characterized by progressive degeneration of the brain, which may involve an increase in oxidative stress, a decrease in antioxidant enzymes, and consequent disruption of the redox dynamic balance (Yu et al., 2024)
It consists of the first 29 amino acids of the natural GHRH molecule, which is the shortest fragment that retains full functional activity
Under these conditions, the enzyme -glutamylcysteine ligase continues to produce large quantities of -glutamylcysteine, which is converted by -glutamyl cyclotransferase into 5-oxoproline (Figure 1C)
GltT was required for meningococcal survival within phagocytic cells (Tal et al., 2011) and in human whole blood (Li et al., 2009)
Methyl conjugation occurs through a family of enzymes called methyl transferases
Supporting this mechanism, studies in animal models demonstrate that L-carnitine administration increases the expression of mitochondrial superoxide dismutase-2 (SOD2), reduces markers of inflammation, and alleviates overall oxidative burden (63)
