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The modification was developed to help enhance the half-life of the protein and allow it to obstruct the normal FOXO4 function

Its significance is rooted in its endogenous nature

In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 g) and vitamin B 12 (100 g) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)

You cannot "process your way" out of a serotonin deficiency any more than you can think your way out of a vitamin D deficiency

Cell Death and Disease , 7 (7), e2312

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