Selenoproteins in nervous system development and function
Most current animal studies rely on traditional OVX rodent models or monoculture cellular assays, which, although informative for bone loss mechanisms, are insufficient for recapitulating the complex bonevascularimmune interactions seen in humans
Thioredoxin glutathione reductase (TGR) is essential for schistosome survival and a validated drug target
As a potent antioxidant, glutathione (GSH) is a type of peptide (a tripeptide) made up of three amino acids: glycine, cystine, and glutamic acid
It is a hypometabolic state with impairment in multiple metabolic pathways linked to m -Dys with impaired OXPHOS and reduced ATP production 207
Despite ease of delivery, little controlled clinical research data exist evaluating the effects of oral GSH supplementation