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Although extremely rare, hydroxocobalamin injections can also cause serious side effects such as a major allergic reaction or irregular heartbeats (palpitations)

Cardiovascular effects: Glucagon receptor agonism (via retatrutide) and GLP-1 receptor agonism have been associated with modest increases in heart rate as a class effect

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[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Miyoshi H, Souza SC, Zhang HH, Strissel KJ, Christoffolete MA, Kovsan J, et al

When to seek medical advice: Persistent or worsening injection site reactions (increasing redness, warmth, or discharge suggesting infection) Severe or persistent headaches Chest pain or palpitations Unexplained muscle weakness or cramps New or worsening neurological symptoms despite treatment Unexpected bleeding or bruising For non-emergency concerns, contact your GP or NHS 111