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doi: 10.1016/j.immuni.2010.07.009 53 ThatcherTHMcHughNAEganRWChapmanRWHeyJATurnerCKet al

This design was selected because the estimate of within-arm standard deviation (SD) from the external pilot study had a wide confidence interval and the interim analysis would allow for a more accurate estimation of the SD as a basis for assessing whether the expected effect size could be feasibly demonstrated

Some studies link heavy marijuana use with a higher incidence of gum disease (periodontitis), which can progress to tooth loss if not managed properly

They weren't exactly pushing him to do this

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