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Endothelial cell adhesion molecules are glycoproteins, mainly including selectin, integrin, and immunoglobulin families, which are used for cell recruitment and signal transduction

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Key findings: Adults using melatonin for 1+ year were more likely to develop heart failure than non-users Those taking melatonin long-term were 3.5 times more likely to be hospitalized for heart failure All-cause mortality risk was also elevated in the long-term melatonin group Critical context: This study is observational and has not yet been peer-reviewed

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It also influences epigenetic methylation patterns in animal aging models