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364 The affected astrocytes demonstrate profound loss of function, in particular impaired K + buffering, 365,366 compromised H + transport, 367 and substantial decrease in glutamate uptake

Similar content being viewed by others Introduction The mechanisms involved in the triggering of autoimmune aggression against beta cells, which leads to clinically overt type 1 diabetes (T1D), are still poorly understood, but a complex interaction between genetic, 1 immunologic, 2 environmental 3 and epigenetic 4 factors has been repeatedly postulated

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