With subsequent phosphorylation of c-Jun and enhanced transcription of AP-1 responsive genes, the stage is set for signal transduction for stress response, proliferation or apoptosis pathways
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Bufotalin (BT) is a steroid lactone isolated from Venenum bufonis
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It increases the tone of the detrusor urinae muscle , usually producing a contraction sufficiently strong to initiate micturition and empty the bladder It stimulates gastric motility , increases gastric tone, and often restores impaired rhythmic peristalsis Because of the selective action of bethanechol, nicotinic symptoms of cholinergicstimulation are usually absent or minimal bethanechol is not hydrolyzed by cholinesterase enzymes, resulting in a longer duration of action compared to acetylcholine and other enzyme-sensitive choline esters FDA Approved Indications: To promote emptying of the urinary bladder, including: (but rarely used) Postoperative urinary retention (POUR) Postpartum nonobstructive urinary retention Neurogenic atony of the urinary bladder with retention of urine
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