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Mol Psychiatry (2009) 14(696704):647.10.1038/mp.2008.26 263 GiganteADBondDJLaferBLamRWYoungLTYathamLN

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The one-tailed (right) p -value, which represents the empirical estimate of the statistical significance of the correlation coefficient, is determined by calculating the proportion of permutations for which the correlation coefficient value is greater than or equal to the original statistic derived from non-permuted data as previously described ( FIGURE 6 FIGURE 7 This approach has already been applied to the examination of reproducibility in in vitro metabolomics studies ( Drug reactive metabolites are thought to be a major trigger of hepatotoxicity, in particular of idiosyncratic metabolic DILI

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