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High-dose supplementation, particularly hydroxocobalamin injections, has been associated with acne-like eruptions and rosacea flare-ups in susceptible individuals

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These injections begin to improve energy levels and reduce fatigue symptoms after their administration within 24-48 hours

NICE guidance on type 2 diabetes management recommends considering vitamin B12 monitoring in patients on long-term metformin, particularly those with anaemia or neuropathy