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However, researchers also noted that the overall clinical effect appeared limited and difficult to reproduce consistently across larger populations

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Neurosci Lett 386:7881 Lorch S, Lightfoot R, Ohshima H, Virag L, Chen Q, Hertkorn C, Weiss M, Souza J, Ischiropoulos H, Yermilov V, Pignatelli B, Masuda M, Szabo C (2002) Detection of peroxynitrite-induced protein and DNA modifications

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With the above cost of production, a critical analysis of Spirulina production costs reveals that the culture medium, harvesting, and drying stages represent substantial portions of the overall expenditure