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As the master antioxidant, glutathione recycles other antioxidants in the body such as alpha lipoic acid, vitamin C and vitamin E and they rely on glutathione to operate
Endothelial dysfunction is associated with decreased bioavailability of nitric oxide (NO) due to an increase in ROS, with a similar physiological change seen in cases of decreased GSH pools [16]
This can result in oxidative stress and muscle damage
This GSH-responsive behavior not only caused contrast-enhanced magnetic resonance imaging, but also contributed to the tumor site-specific release of loaded therapeutic agents for realizing selective cancer therapy (Klochkov et al., 2021
Ran-GST pull-down assays using various PlexinB1 deletion constructs demonstrated that the Rho binding domain (RBD) of PlexinB1 is required for the interaction of Ran with PlexinB1 (Supplementary Fig