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[4] Kummer A, Pulford BE, Ishii DN, Seigel GM

KDX1 encodes a Protein kinase that is implicated in Slt2p mitogen-activated (MAP) kinase signalling pathway

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Consistent findings across studies: Wrinkle reduction of 20 to 30 % in 12 weeks Increased skin elasticity of 25 to 40 % Improved hydration (increased stratum corneum hydration) Reduction of hyperpigmentation of ~30 % Thickening of the dermis (direct DXA measurements) Why it matters: GHK-Cu is the best-validated anti-aging peptide in dermatology

8 Conclusion In conclusion, the consideration of the effects of tamoxifen on both tumor and non-tumor cells through oxidative stress involves the interaction of several mechanisms associated with the therapeutic success, acquired resistance, or toxicity of tamoxifen