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The analysis of Epithalon effects suggests that the tetrapeptide participates in the mechanisms of transcription common for the epiphysis and retina and may be associated with positive effects observed in clinical research

The 10 structural models with the lowest associated energy from 1000 calculated structural models were used to prepare figures using the PyMOL Molecular Graphics System, Version 2.4 (Schrdinger, LLC)

In general, upon binding Tau protects MTs from depolymerization and is highly likely to be a factor in the induction of MT polymerization (Barbier et al., 2019), thus playing a key role in MT dynamics and resulting in increased MT growth rates and reduced dissociation rates (Murphy et al., 1977

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