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Clin Colorectal Cancer 1(1):55-9, 2008

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Through the FGF21SIRT1 axis, FGF21 may shift from a protective to a dysregulatory role, exacerbating hepatic lipid accumulation and metabolic imbalance in advanced disease stages

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Additionally, our metabolomic analysis revealed a marked decline in pro-inflammatory lipid mediators such as 9,10-DiHOME and quinolinic acid, alongside an increase in anti-inflammatory and pro-resolving lipids including ()15-HETE