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This prevents beta-3 receptor desensitization while maintaining the appetite suppression and metabolic benefits of tirzepatide

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[8] Substrates [edit] While CROT's canonical substrate is octanoyl-CoA, CROT is also known to be able to catalyze the deacylation of numerous acyl-CoAs, such as acetyl-CoA, propionyl-CoA, butyryl-CoA, and hexanoyl-CoA

doi: 10.1038/s41419-022-05115-x 20 DuJWangTLiYZhouYWangXYuXet al

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