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Over time, stress, environmental toxins, aging, and illness can deplete glutathione levels

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The limited availability of clinical data on O-GlcNAcylation presents a critical gap, rendering the translational relevance of preclinical findings uncertain

Therefore, as soon as MTX treatment starts, routine monitoring of serum creatinine and plasma MTX levels is crucial to predict the onset of renal failure

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tb is mainly driven by Th1 cells that secrete IFN- , IL-2, and TNF-