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So why are these methods so unsuccessful

It is important to note that there are other features of tobacco control policy that are not directly related to initiation and cessation (e.g., tobacco companies responding to FDA regulatory changes in an attempt to undermine those changes), so the modeling decision to focus on a specific policy question versus initiation or cessation needs to discussed early in model conceptualization

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When estrogen levels rise, testosterone levels fall, or breast tissue becomes more sensitive to estrogen, male breast enlargement can follow

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