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variation in this gene makes the greatest contribution to serum UA in both European and non-European populations 4

Cells 12 , 1207 (2023)

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Toxicology, 265 (8086), 30

Under basal conditions, NRF2 is kept at a low cellular concentration by the activity of Keap1, its major regulator, keeping the expression of NRF2-regulated genes at low levels in order to preserve the correct redox homeostasis [152]