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2 In pernicious anemia, the deficient levels of vitamin B12 are due to the body lacking the intrinsic factor that forms a complex with vitamin B12 which allows absorption into the gut

Simultaneously, the preservation of SAM levels maintains cellular capacity for critical methylation reactions including histone modifications, DNA methylation, and protein methylation that regulate gene expression and protein function

Mauras N, Haymond MW

Conversely, isoniazid and pyrazinamide (tuberculosis drugs) are structural analogs of niacin that can interfere with niacin metabolism, potentially precipitating pellagra in rare cases

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That consistency, over time, is what produces strength and physique progress