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HSCs, the primary producers of ECM, play an indispensable role in the pathogenesis of liver fibrosis ( The pathogenesis of liver fibrosis is complex, with sustained HSC activation and ECM deposition due to chronic liver injury being major contributors ( in vitro and animal models has revealed multiple pathways by which glycyrrhizin inhibits HSC activation

Mechanistically, SLC25A39 deficiency induced mitochondrial dysfunction, characterized by excessive mitochondrial reactive oxygen species (ROS), reduced membrane potential, diminished adenosine triphosphate (ATP) synthesis, aberrant mitochondrial permeability transition pore (mPTP) opening, and cytochrome c release

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El glutatin, como GSSG oxidado, seala el malestar de la clula, y la proporcin de GSH/GSSG acta como indicador o barmetro del bienestar de la clula

We also proposed potential biological mechanisms, such as glial cells (microglia astrocytes), autophagy, and apoptosis