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Imoto S, Kono M, Suzuki T, Shibuya Y, Sawamura T, Mizokoshi Y, et al

UK guidance (MHRA and NICE) advises checking B12 levels in patients on metformin who develop symptoms of deficiency (anaemia, neuropathy) and considering periodic monitoring in those on long-term therapy

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doi: 10.1002/DMRR.3678 174 GeravandiSRichardsonSPuglieseAMaedlerK

doi: 10.1186/s12935-018-0504-4 92 KippAP

(NIH) In adults over 55 with type-2 diabetes, GSH supplementation improved glutathione stores and reduced DNA oxidative damage (8-OHdG) while lowering HbA1c.(NIH) However, short-term trials (4 weeks) in healthy adults showed no measurable change in blood GSH, highlighting absorption variability