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Accordingly, inventors of the present invention have provided various embodiments showing at least 30 %, at least 50 %, at least 70 % and at least 90 % release over 24 hrs when tested in an In Vitro study using a Franz Diffusion Cell employing a dialysis membrane with l2-l4kd molecular weight cut off

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Polarized macrophages were stimulated with 500 nM PMA at 37 C for 23 h and washed three times in RPMI 1640