Lancet 395 , 14171418 (2020)
doi: 10.2337/db20-0361
Long-term oral exposure to PS-MPs causes significant deficits in learning and memory behaviors in mice (44), PS-MPs accumulate in the hippocampal region, affecting the expression of genes related to neural activity and synaptic proteins, inducing neuroinflammation, reducing the expression of immediate early genes, and altering synaptic protein profiles, ultimately leading to impaired learning and memory (44).In study on zebrafish (Symphysodon aequifasciatus) (45), micro- and nanoplastics were found to induce neurobehavioral toxicity through the brain-gut-microbiota axis
Most studies indicate that dysbiosis in fecal and duodenal specimens of CD patients is marked by an increased presence of Gram-negative bacteria, such as Bacteroides and Enterobacteriaceae, and a reduced number of beneficial Gram-positive bacteria, like Bifidobacterium spp., when compared to healthy individuals (31)
Biochem Biophys Res Commun 326:371377 Supplisson S, Roux MJ (2002) Why glycine transporters have different stoichiometries
Its mechanisms mainly involve disordered iron metabolism, lipid peroxide deposition, and an imbalance of the antioxidant system