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Additional studies have investigated its effects on melatonin secretion and circadian rhythm regulation through the pineal gland

In this paper, we present a new integrated model for hepatic glutathione metabolism including one-carbon metabolism and use it to investigate how the activation of certain enzymes by estradiol in one-carbon metabolism and glutathione metabolism leads to dramatic changes in reaction velocities and metabolite concentrations, including GSH and the GSH synthesis rate

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